GINAPS

Paclitaxel and curcumin co-loaded mixed micelles: Improving in vitro efficacy and reducing toxicity against Abraxane®

Paclitaxel (PTX) is one of the most effective antineoplastic drugs employed for breast and ovarian cancer therapy. However, the neurotoxicity associated with PTX administration represents one of its main drawbacks reducing patient life quality. …

Supramolecular effect of acetate on chitin gelling medium: Structural properties and protein interaction

In this work, the influence of Sodium Acetate Trihydrate (SAT) on the gelling stage of a chitin hydrogel was studied. Characterization techniques, such as FTIR, Raman, solid-state NMR, Dielectric Spectroscopy, Small-angle X-ray scattering (SAXS), …

Integrated SPE-Self assembled MEPS platform for ultrasensitive determination of mononitrophenols in water: Experimental, computational and applicability studies

Integrated analytical approaches can be used to determine the trace concentrations of analytes in water matrices. Here we designed and compared two novel and facile, integrated polysaccharide adsorbent SPE-Self assembled MEPS (solid phase extraction …

Acid functionalized coal fly ashes: New solid catalysts for levulinic acid esterification

Coal fly ash (CFA) from different sources (CFA 5, 10, 13) and different size fractions (> or < 75 μm) were characterized and used as inorganic supports for sulfonic acid functionalization by two methodologies including one-pot organosilylation …

Assessment of graphitized coal ash char concentrates as a potential synthetic graphite source

Coal ash char concentrates from four countries (Portugal, Poland, Romania, and South Africa) were prepared, characterised, and graphitized under the scope of the Charphite project (Third ERA-MIN Joint Call (2015) on the Sustainable Supply of Raw …

Dual adsorbent-photocatalytic keratin-TiO2nanocomposite for trimethoprim removal from wastewater

Trimethoprim is an emerging pollutant that has been found in ground water in alarming concentrations. Thus, the development of economical and efficient advanced water treatment technologies is crucially needed. In this paper, a keratin hydrogel with …

Enhanced chitin gel with magnetic nanofiller for lysozyme purification

In this study, we have investigated the impact of superparamagnetic magnetite nanoparticle (Fe3O4) inclusion on the chitin polysaccharide structure, together with its surface chemistry influence on the adsorption of lysozyme (LYZ). Magnetic …

Heterogeneous acid catalysts prepared by immobilization of H3PW12O40 on silica through impregnation and inclusion, applied to the synthesis of 3H-1,5-benzodiazepines

Solid acid catalysts were successfully prepared using mesoporous silica (MESOSI) as support and tungstophosphoric acid (KTPA) as active phase, which was incorporated by impregnation (MESOSI#KTPA) and inclusion (MESOSI@KTPA). TEM (transmission …

Lactoferrin purification and whey protein isolate recovery from cheese whey using chitosan mini-spheres

Direct protein purification from raw materials by chromatographic media represents an enormous challenge, especially when particulate solids and high charge solute are present. In this sense, protein purification from cheese whey is an excellent …

Low cost and regenerable composites based on chitin/bentonite for the adsorption potential emerging pollutants

Composites based on bentonite and chitin were prepared and its application for trimethoprim (TMP) adsorption from aqueous solution was investigated. Composites were characterized by ATR-FTIR, XRD, DSC and TGA. Characterization data revealed the …